Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 16/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 16/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538847 | 0.89 | ADRB1 (0.48) | ADRB1ADRB3ADRB2MAPTMEN1 | |
| SCHEMBL6539522 | 0.86 | ADRB1 (0.52) | ADRB1ADRB3BACE1ADRB2MAPT | |
| SCHEMBL6540426 | 0.85 | BACE1 (0.42) | ADRB1ADRB3BACE1ADRB2MAPT | |
| SCHEMBL6539352 | 0.82 | ADRB1 (0.62) | ADRB1ADRB3BACE1ADRB2MEN1 | |
| SCHEMBL6540414 | 0.82 | ADRB1 (0.53) | ADRB1ADRB3BACE1ADRB2MEN1 | |
| SCHEMBL6538543 | 0.81 | BACE1 (0.43) | ADRB1ADRB3BACE1 | |
| SCHEMBL6540224 | 0.81 | BACE1 (0.43) | ADRB1ADRB3BACE1 | |
| SCHEMBL6539067 | 0.81 | ADRB1 (0.49) | ADRB1ADRB3BACE1ADRB2 | |
| SCHEMBL6538478 | 0.78 | KMT2A (0.47) | ADRB1ADRB3BACE1ADRB2MEN1 | |
| SCHEMBL6539215 | 0.76 | ADRB3 (0.72) | ADRB1ADRB3ADRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |