Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6542791 | 0.94 | LMNA (0.63) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6542118 | 0.85 | UTS2R (0.57) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6541691 | 0.84 | LMNA (0.60) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6541397 | 0.83 | LMNA (0.64) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6542002 | 0.82 | LMNA (0.63) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6542745 | 0.82 | LMNA (0.63) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6542664 | 0.81 | LMNA (0.64) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6541903 | 0.81 | LMNA (0.51) | LMNAHTTALDH1A1MEN1KMT2A | |
| SCHEMBL6542576 | 0.81 | UTS2R (0.60) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6176052 | 0.80 | CACNA1B (0.53) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248607-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1248607-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001045694-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |