SCHEMBL654148

SCHEMBL654148

N#CCC(=O)NCc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 1.00
GAA P10253 2/20 0.59
KMT2A Q03164 4/20 0.58
MEN1 O00255 2/20 0.58
ALDH1A1 P00352 4/20 0.53
HTT P42858 1/20 0.53
HPGD P15428 1/20 0.53
LMNA P02545 1/20 0.53
RAB9A P51151 1/20 0.51
HSP90AA1 P07900 1/20 0.51
MAPT P10636 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11253671 0.98 MCL1 (0.96) MCL1GAAKMT2AMEN1ALDH1A1
SCHEMBL2263308 0.90 MCL1 (0.81) MCL1GAAKMT2AMEN1ALDH1A1
SCHEMBL2263988 0.86 MCL1 (0.74) MCL1GAAKMT2AMEN1ALDH1A1
SCHEMBL22803077 0.85 MCL1 (0.73) MCL1KMT2AMEN1ALDH1A1HPGD
SCHEMBL29249541 0.84 MCL1 (0.72) MCL1GAAKMT2AMEN1LMNA
SCHEMBL19277778 0.82 MCL1 (0.69) MCL1GAAKMT2AMEN1ALDH1A1
SCHEMBL2265490 0.82 MCL1 (0.70) MCL1GAAHPGDRAB9AL3MBTL1
SCHEMBL12389322 0.82 MCL1 (0.70) MCL1GAAKMT2AMEN1ALDH1A1
SCHEMBL2264964 0.82 MCL1 (0.70) MCL1KMT2AALDH1A1HTTHPGD
SCHEMBL2268566 0.82 MCL1 (0.70) MCL1KMT2AALDH1A1HTTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115974721-B Method for synthesizing 2-carbonyl substituted nitrile compound through 2, 2-trifluoroethyl ketone 平顶山学院 2024-07-02 CN claimed
CN-115974721-A Method for synthesizing 2-carbonyl substituted nitrile compound through 2,2,2-trifluoroethyl ketone 平顶山学院 2023-04-18 CN claimed
CN-110709440-B Polyurethane foams based on polyether carbonate polyols 科思创德国股份有限公司 2022-03-18 CN claimed
EP-3630859-B1 POLYURETHANE FOAMS BASED ON POLYETHER CARBONATE POLYOLS COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) 2021-06-23 EP claimed
EP-3630859-A1 POLYURETHANE FOAMS BASED ON POLYETHERCARBONATE POLYOLS Covestro Deutschland AG (DE) 2020-04-08 EP claimed
US-20200087438-A1 POLYURETHANE FOAMS BASED ON POLYETHERCARBONATE POLYOLS COVESTRO DEUTSCHLAND AG (DE) 2020-03-19 US claimed
CN-110709440-A Polyurethane foams based on polyether carbonate polyols 科思创德国股份有限公司 2020-01-17 CN claimed
WO-2018219893-A1 POLYURETHANE FOAMS BASED ON POLYETHERCARBONATE POLYOLS COVESTRO DEUTSCHLAND AG (DE) 2018-12-06 WO claimed
EP-3409704-A1 POLYURETHANE FOAMS BASED ON POLYETHER CARBONATE POLYOLS Covestro Deutschland AG (DE) 2018-12-05 EP claimed
US-20260070877-A1 FLUORINE-CONTAINING PYRIDONE COMPOUND AND METHOD FOR PRODUCING SAME UNIMATEC CO., LTD. (JP) 2026-03-12 US disclosed
EP-4628482-A1 FLUORINE-CONTAINING PYRIDONE COMPOUND AND METHOD FOR PRODUCING SAME Unimatec Co., Ltd. (JP) 2025-10-08 EP disclosed
CN-115974721-B Method for synthesizing 2-carbonyl substituted nitrile compound through 2, 2-trifluoroethyl ketone 平顶山学院 2024-07-02 CN disclosed
CN-118271238-A 2-Cyanoacrylamides derivatives and use thereof 四川大学 2024-07-02 CN disclosed
WO-2024116528-A1 FLUORINE-CONTAINING PYRIDONE COMPOUND AND METHOD FOR PRODUCING SAME ユニマテック株式会社 2024-06-06 WO disclosed
US-4537781-A Pharmaceutically useful malonamides RESEARCH CORPORATION (US) 1985-08-27 US disclosed
EP-0135189-A2 Pharmaceutically useful malonamides Research Corporation (US) 1985-03-27 EP disclosed
US-4393217-A ANXIOLYTICS, ANTIDEPRESSANTS AMERICAN CYANAMID COMPANY (US) 1983-07-12 US disclosed
US-4104273-A Derivatives of 3-cyano-pyrid-2-ones ROHM AND HAAS COMPANY (US) 1978-08-01 US disclosed
US-4028084-A Derivatives of 3-carboxy pyrid-2-ones ROHM AND HAAS COMPANY (US) 1977-06-07 US disclosed
US-3985763-A DYESTUFFS BAYER AKTIENGESELLSCHAFT (DT) 1976-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070877-A1 FLUORINE-CONTAINING PYRIDONE COMPOUND AND METHOD FOR PRODUCING SAME NR4A1, POF1B, NR0B2 MCL1 994/4885GAA 4830/4885KMT2A 1362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.