Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | HTR7 | P34969 | 6/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 6/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | HTR2B | P41595 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607975 | 1.00 | CHRM3 (0.52) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL6542212 | 0.99 | CHRM3 (0.51) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7706323 | 0.99 | CHRM3 (0.51) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| SCHEMBL7604110 | 0.83 | CHRM3 (0.56) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7604699 | 0.82 | CHRM3 (0.55) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7603951 | 0.82 | CHRM3 (0.55) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7706358 | 0.82 | CHRM3 (0.55) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL6541313 | 0.82 | CHRM3 (0.55) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7608424 | 0.79 | HTR1A (0.76) | CHRM3HTR1AHTR7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL6542136 | 0.79 | HTR1A (0.72) | CHRM3HTR1AHTR7CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1052982-A4 | AMINOTETRALINS AS 5-HT 1D$g(a)? AGONISTS | LILLY CO ELI (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1052982-A1 | AMINOTETRALINS AS 5-HT 1D$g(a)? AGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1998048786-A1 | AMINOTETRALINS AS 5-HT1Dα AGONISTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |