Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6542111 | 0.95 | EDNRA (0.47) | EDNRALMNAGABRA1GABRB2ALDH1A1 | |
| SCHEMBL6542057 | 0.95 | EDNRA (0.51) | EDNRALMNAGABRA1GABRB2ALDH1A1 | |
| SCHEMBL6541434 | 0.89 | EDNRA (0.44) | EDNRAALDH1A1L3MBTL1HCRTR2PTGS2 | |
| SCHEMBL6541682 | 0.86 | EDNRA (0.61) | EDNRALMNAGABRA1GABRB2ALDH1A1 | |
| SCHEMBL6542600 | 0.86 | EDNRA (0.44) | EDNRALMNAALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL6541832 | 0.85 | EDNRA (0.46) | EDNRALMNAALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL6542215 | 0.85 | EDNRA (0.44) | EDNRALMNAGABRA1GABRB2ALDH1A1 | |
| SCHEMBL6542581 | 0.85 | EDNRA (0.43) | EDNRALMNAALDH1A1L3MBTL1HCRTR2 | |
| SCHEMBL6541202 | 0.84 | EDNRA (0.51) | EDNRALMNAGABRA1GABRB2ALDH1A1 | |
| SCHEMBL6542606 | 0.83 | EDNRA (0.43) | EDNRALMNAALDH1A1L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009743-B1 | CERTAIN BENZOTHIAZINE DIOXIDE ENDOTHELIN ANTAGONISTS AND PROCESSES FOR THEIR PREPARATION | WARNER LAMBERT CO (US) | 2004-06-30 | — | — | EP | claimed |