Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6542600 | 0.89 | EDNRA (0.44) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6541832 | 0.88 | EDNRA (0.46) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6542057 | 0.88 | EDNRA (0.51) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6542147 | 0.86 | EDNRA (0.57) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6542215 | 0.85 | EDNRA (0.44) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6542684 | 0.85 | EDNRA (0.42) | EDNRAPTGS2ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL6542033 | 0.85 | EDNRA (0.60) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6541434 | 0.85 | EDNRA (0.44) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6541685 | 0.85 | EDNRA (0.47) | EDNRAPTGS2ALDH1A1L3MBTL1HTT | |
| SCHEMBL6541388 | 0.85 | EDNRA (0.43) | EDNRAPTGS2ALDH1A1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009743-B1 | CERTAIN BENZOTHIAZINE DIOXIDE ENDOTHELIN ANTAGONISTS AND PROCESSES FOR THEIR PREPARATION | WARNER LAMBERT CO (US) | 2004-06-30 | — | — | EP | claimed |