Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.63 |
| ▸ | PRCP | P42785 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 6/20 | 0.51 |
| ▸ | HTR2B | P41595 | 6/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21924071 | 1.00 | SIGMAR1 (0.63) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL30285859 | 1.00 | SIGMAR1 (0.63) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL4661810 | 1.00 | SIGMAR1 (0.63) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL10785005 | 0.98 | SIGMAR1 (0.60) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL6542312 | 0.94 | SIGMAR1 (0.56) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL18440245 | 0.92 | SIGMAR1 (0.54) | SIGMAR1PRCPIDO1 | |
| Dimethylamine SCHEMBL6542290 | 0.91 | SIGMAR1 (0.55) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL2064332 | 0.90 | SIGMAR1 (0.56) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL11460515 | 0.90 | SIGMAR1 (0.56) | SIGMAR1PRCPHTR2AHTR2CHTR2B | |
| SCHEMBL9294850 | 0.86 | SIGMAR1 (0.56) | SIGMAR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1052982-A4 | AMINOTETRALINS AS 5-HT 1D$g(a)? AGONISTS | LILLY CO ELI (US) | 2004-10-06 | — | — | EP | disclosed |
| US-6355674-B1 | PSYCHOLOGICAL DISORDERS; ANTISEROTONINE AGENTS | ELI LILLY AND COMPANY | 2002-03-12 | — | — | US | disclosed |
| EP-1052982-A1 | AMINOTETRALINS AS 5-HT 1D$g(a)? AGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1998048786-A1 | AMINOTETRALINS AS 5-HT1Dα AGONISTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |