Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6542075 | 0.88 | EDNRA (0.49) | EDNRAMAPTTP53AKR1C3AKR1C2 | |
| SCHEMBL6542066 | 0.86 | EDNRA (0.63) | EDNRAALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL6542021 | 0.86 | MAPT (0.40) | EDNRAALDH1A1KDM4EHTTMAPT | |
| SCHEMBL6541895 | 0.86 | MAPT (0.40) | EDNRAALDH1A1KDM4EHTTMAPT | |
| SCHEMBL6541201 | 0.83 | EDNRA (0.53) | EDNRAALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL6541351 | 0.83 | EDNRA (0.64) | EDNRAALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL6542033 | 0.81 | EDNRA (0.60) | EDNRAALDH1A1HTTCYP1A2CYP2C9 | |
| SCHEMBL6542045 | 0.81 | EDNRA (0.55) | EDNRAALDH1A1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL6542488 | 0.79 | EDNRA (0.78) | EDNRAALDH1A1HTTCYP1A2CYP2C9 | |
| SCHEMBL6541145 | 0.73 | EDNRA (0.66) | EDNRAMAPTTP53AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009743-B1 | CERTAIN BENZOTHIAZINE DIOXIDE ENDOTHELIN ANTAGONISTS AND PROCESSES FOR THEIR PREPARATION | WARNER LAMBERT CO (US) | 2004-06-30 | — | — | EP | claimed |