Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6541959 | 0.88 | EDNRA (0.40) | EDNRAALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL6541343 | 0.87 | EDNRA (0.36) | EDNRAALDH1A1L3MBTL1HTTKDM4E | |
| SCHEMBL6542549 | 0.84 | EDNRA (0.46) | EDNRAALDH1A1L3MBTL1HTTKDM4E | |
| SCHEMBL6541894 | 0.81 | ELANE (0.38) | RAB9AHSP90AA1PTGESPAX8LMNA | |
| SCHEMBL6542734 | 0.79 | EDNRA (0.40) | EDNRAALDH1A1L3MBTL1HTTPTGES | |
| SCHEMBL6541543 | 0.78 | LMNA (0.52) | ALDH1A1L3MBTL1HTTKDM4EHSD17B10 | |
| SCHEMBL6541388 | 0.78 | EDNRA (0.43) | EDNRAALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL6542684 | 0.76 | EDNRA (0.42) | EDNRAALDH1A1L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL6542717 | 0.76 | EDNRA (0.38) | EDNRAALDH1A1L3MBTL1HTTNPC1 | |
| SCHEMBL6542600 | 0.75 | EDNRA (0.44) | EDNRAALDH1A1L3MBTL1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009743-B1 | CERTAIN BENZOTHIAZINE DIOXIDE ENDOTHELIN ANTAGONISTS AND PROCESSES FOR THEIR PREPARATION | WARNER LAMBERT CO (US) | 2004-06-30 | — | — | EP | claimed |