Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544430 | 0.92 | MMP13 (0.42) | MMP13BCL2ALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL6544736 | 0.90 | MEN1 (0.46) | BCL2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14855362 | 0.89 | PPARG (0.35) | MMP13BCL2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6544272 | 0.89 | MMP13 (0.38) | MMP13BCL2ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14855569 | 0.88 | BCL2 (0.34) | MMP13BCL2ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14855106 | 0.88 | ST14 (0.37) | MMP13BCL2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6543773 | 0.88 | BCL2 (0.45) | BCL2ACACBLMNA | |
| SCHEMBL6544794 | 0.86 | BCL2 (0.43) | BCL2ALDH1A1LMNA | |
| SCHEMBL6703682 | 0.85 | BACE1 (0.46) | BCL2ALDH1A1L3MBTL1PKMLMNA | |
| SCHEMBL6543570 | 0.85 | MERTK (0.40) | ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |