Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 2/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544046 | 0.85 | PTPN1 (0.38) | ALDH1A1GAAMAPTPTPN1CYP3A4 | |
| SCHEMBL7075552 | 0.75 | CYP3A4 (0.42) | ALDH1A1MAPTPTPN1CYP3A4CHRM1 | |
| SCHEMBL6543977 | 0.75 | PTPN1 (0.41) | ALDH1A1GAAMAPTPTPN1CYP3A4 | |
| SCHEMBL29311940 | 0.73 | PTPN1 (0.40) | PTPN1 | |
| SCHEMBL26081261 | 0.70 | KMT2A (0.40) | MAPTPTPN1ADRA1ALMNA | |
| SCHEMBL8408701 | 0.69 | CYP3A4 (0.41) | ALDH1A1GAAMAPTPTPN1CYP3A4 | |
| SCHEMBL10820980 | 0.69 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTCYP3A4CHRM1 | |
| Dichloroxylenol SCHEMBL29367847 | 0.69 | ALDH1A1 (0.61) | ALDH1A1GAAMAPTCYP3A4CHRM1 | |
| Dichloroxylenol SCHEMBL574277 | 0.69 | ALDH1A1 (0.61) | ALDH1A1GAAMAPTCYP3A4CHRM1 | |
| SCHEMBL20090022 | 0.69 | PTPN1 (0.46) | ALDH1A1MAPTPTPN1CYP3A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1255386-C | Substituted fused heterocyclic compound | SANKYO CO (JP) | 2006-05-10 | — | — | CN | disclosed |
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| CN-1280570-A | Substituted fused heterocyclic compounds | SANKYO CO (JP) | 2001-01-17 | — | — | CN | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |