SCHEMBL6544405

SCHEMBL6544405

CC(C)(C)c1cc(NC(=O)O)ccn1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.61
LMNA P02545 5/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
NPC1 O15118 1/20 0.57
RAB9A P51151 1/20 0.57
ALDH1A1 P00352 2/20 0.52
HDAC4 P56524 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HTT P42858 1/20 0.47
SMARCA2 P51531 2/20 0.47
SMARCA4 P51532 2/20 0.47
MEN1 O00255 1/20 0.46
MAPK1 P28482 1/20 0.46
KMT2A Q03164 1/20 0.46
AR P10275 2/20 0.43
MAPK14 Q16539 2/20 0.42
MAPK13 O15264 1/20 0.42
MAPK12 P53778 1/20 0.42
MAPK11 Q15759 1/20 0.42
ANO1 Q5XXA6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16369790 0.87 SMARCA2 (0.51) PRKCILMNASMN1; SMN2NPC1RAB9A
SCHEMBL13842708 0.86 PRKCI (0.61) PRKCILMNASMN1; SMN2NPC1RAB9A
SCHEMBL13015661 0.85 PRKCI (0.59) PRKCILMNASMN1; SMN2NPC1RAB9A
SCHEMBL3616240 0.83 SMARCA2 (0.66) HDAC4HDAC6SMARCA2SMARCA4SORT1
SCHEMBL15880685 0.78 SMARCA2 (0.65) HDAC4HDAC6SMARCA2SMARCA4MEN1
SCHEMBL22601563 0.76 PRKCI (0.49) PRKCILMNASMN1; SMN2NPC1RAB9A
SCHEMBL28940889 0.74 PRKCI (0.46) PRKCISMARCA2SMARCA4KMT2AAR
SCHEMBL28723867 0.74 SMARCA2 (0.44) PRKCISMN1; SMN2SMARCA2SMARCA4KMT2A
SCHEMBL23213553 0.74 P4HTM (0.45) LMNASMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL15880501 0.74 PRKCI (0.62) PRKCILMNASMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117242060-A Isoindolinone compounds 蒙特罗萨医疗公司 2023-12-15 CN disclosed
US-6680329-B2 N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants SANOFI-SYNTHELABO (FR) 2004-01-20 US disclosed
US-20030207920-A1 N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants SANOFI-AVENTIS (FR) 2003-11-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030207920-A1 N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants PROC, VKORC1, SERPINC1 PRKCI 4188/4885LMNA 1254/4885SMN1; SMN2 4088/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.