Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6545022 | 0.99 | F2R (0.56) | F2RMAPTKDM4ENPC1RAB9A | |
| SCHEMBL6544351 | 0.89 | F2R (0.49) | F2RMAPTKDM4ENPC1RAB9A | |
| Bromide SCHEMBL6544687 | 0.83 | F2R (0.56) | F2RMAPTKDM4ENPC1RAB9A | |
| Bromide SCHEMBL6543938 | 0.82 | F2R (0.37) | F2RMAPTKDM4ENPC1RAB9A | |
| Bromide SCHEMBL1732339 | 0.82 | F2R (0.65) | F2R | |
| Hydrochloric Acid SCHEMBL1732430 | 0.80 | F2R (0.64) | F2R | |
| Bromide SCHEMBL1732738 | 0.79 | F2R (0.60) | F2RMAPTKDM4ENPC1RAB9A | |
| Bromide SCHEMBL1731325 | 0.79 | F2R (0.56) | F2RMAPTKDM4ENPC1RAB9A | |
| Bromide SCHEMBL6543851 | 0.78 | F2R (0.53) | F2RMAPTKDM4ENPC1RAB9A | |
| SCHEMBL28740926 | 0.78 | F2R (0.56) | F2RMAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-A1 | 2-IMINOPYRROLIDINE DERIVATES | Eisai Co., Ltd. (JP) | 2004-02-25 | — | — | EP | disclosed |