Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.68 |
| ▸ | FRK | P42685 | 1/20 | 0.68 |
| ▸ | CLK2 | P49760 | 1/20 | 0.68 |
| ▸ | GSK3A | P49840 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.68 |
| ▸ | STK3 | Q13188 | 1/20 | 0.68 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.68 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.68 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31179077 | 1.00 | MAPK1 (0.68) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL4897721 | 0.87 | MAPK14 (0.63) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL16794954 | 0.83 | MAPK1 (0.54) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL28132803 | 0.83 | MAPT (0.71) | MAPK1MAPTPDE9AESR1ESR2 | |
| SCHEMBL31179267 | 0.83 | ROCK2 (0.53) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL29612323 | 0.81 | CSF1R (0.70) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL9363357 | 0.81 | CSF1R (1.00) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL19952949 | 0.81 | CSF1R (0.70) | MAPK1ROCK2MAP4K4LCKCSF1R | |
| SCHEMBL6343134 | 0.79 | KDM4E (0.62) | MAPTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29709937 | 0.79 | MAPT (0.75) | MAPTPDE9AESR1ESR2MAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825131-B2 | Quinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20070078154-A1 | Quinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-04-05 | — | — | US | disclosed |
| EP-0942723-B1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078154-A1 | Quinoline potassium channel inhibitors | KCNQ2, KCNQ1, KCNJ2 | MAPK1 1529/4885ROCK2 1973/4885MAP4K4 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.