Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6279799 | 1.00 | MAPT (0.58) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL20703532 | 0.85 | MAPT (0.58) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL6279903 | 0.83 | SMN1; SMN2 (0.84) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL6284661 | 0.81 | KDM4E (0.59) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL6279966 | 0.80 | ALDH1A1 (0.61) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL6286382 | 0.80 | ALDH1A1 (0.69) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL6285194 | 0.80 | KDM4E (0.61) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL6285179 | 0.80 | ALDH1A1 (0.83) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| Bromide SCHEMBL5698583 | 0.79 | KDM4E (0.59) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| Bromide SCHEMBL5698732 | 0.79 | ALDH1A1 (0.68) | MAPTKDM4ELMNAMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027050-B1 | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGY, ASTHMA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-14 | — | — | EP | disclosed |
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |