Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 3/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10851496 | 0.83 | KMT2A (0.77) | KMT2AMEN1ALDH1A1HSD17B10TSHR | |
| SCHEMBL10851096 | 0.81 | KMT2A (0.74) | KMT2AMEN1ALDH1A1HSD17B10TSHR | |
| SCHEMBL10849083 | 0.80 | KMT2A (0.76) | KMT2AMEN1ALDH1A1HSD17B10TSHR | |
| SCHEMBL13174430 | 0.80 | KMT2A (0.74) | KMT2AMEN1ALDH1A1HSD17B10TSHR | |
| SCHEMBL7053642 | 0.80 | PDE4A (0.72) | KMT2AMEN1ALDH1A1PDE4APDE4B | |
| SCHEMBL7056147 | 0.80 | PDE4A (0.60) | KMT2AMEN1ALDH1A1PDE4APDE4B | |
| SCHEMBL7055488 | 0.80 | PDE4A (0.77) | KMT2AMEN1ALDH1A1PDE4APDE4B | |
| SCHEMBL10851472 | 0.80 | KMT2A (0.71) | KMT2AMEN1ALDH1A1HSD17B10TSHR | |
| SCHEMBL6547514 | 0.80 | PDE4A (1.00) | KMT2AMEN1ALDH1A1HSD17B10PDE4A | |
| Hydrochloric Acid SCHEMBL7051870 | 0.79 | PDE4A (0.76) | KMT2AMEN1ALDH1A1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841927-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2004-01-28 | — | — | EP | claimed |
| US-5753666-A | Quinolones and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-05-19 | — | — | US | claimed |
| EP-0841927-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2004-01-28 | — | — | EP | disclosed |
| US-6541480-B2 | Controlling cytokines | SUNTORY LIMITED (JP) | 2003-04-01 | — | — | US | disclosed |
| US-6297248-B1 | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | SUNTORY LIMITED (JP) | 2001-10-02 | — | — | US | disclosed |
| US-5753666-A | Quinolones and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |