SCHEMBL6548245

SCHEMBL6548245

COc1ccc2c3c(cccc13)C(=O)OC2=O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.76
MEN1 O00255 5/20 0.76
POLB P06746 2/20 0.76
PRMT1 Q99873 1/20 0.66
MAPT P10636 6/20 0.64
KDM4E B2RXH2 3/20 0.64
ALDH1A1 P00352 3/20 0.64
LMNA P02545 1/20 0.64
PABPC1 P11940 1/20 0.64
XBP1 P17861 1/20 0.64
NFKB1 P19838 1/20 0.64
HTT P42858 1/20 0.64
SMARCA2 P51531 1/20 0.64
NFKB2 Q00653 1/20 0.64
RELA Q04206 1/20 0.64
TYMS P04818 6/20 0.56
CASP1 P29466 2/20 0.55
CASP7 P55210 2/20 0.55
HSD17B10 Q99714 2/20 0.55
USP2 O75604 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30761754 1.00 KMT2A (0.76) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL12941557 0.85 PRMT1 (0.70) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL11171228 0.81 KMT2A (0.53) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL17726914 0.81 KMT2A (0.53) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL16201008 0.81 PRMT1 (0.64) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL6550616 0.81 PRMT1 (0.69) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL11592771 0.81 KMT2A (0.65) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL7709465 0.80 POLB (0.51) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL16291732 0.79 TYMS (0.53) KMT2AMEN1POLBPRMT1MAPT
SCHEMBL438891 0.79 PRMT1 (1.00) KMT2AMEN1POLBPRMT1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023094231-A1 COMPOSITIONS COMPRISING POLYARYLENE(ETHER)SULFONES BASF SE (DE) 2023-06-01 WO disclosed
US-11193020-B2 Polyarylene ether sulfone comprising naphthalic acid anhydride endgroups BASF SE (DE) 2021-12-07 US disclosed
EP-3577164-B1 POLYARYLENE ETHER SULFONE COMPRISING NAPHTHALIC ACID ANHYDRIDE ENDGROUPS BASF SE (DE) 2021-06-02 EP disclosed
WO-2018141552-A1 POLYARYLENE ETHER SULFONE COMPRISING NAPHTHALIC ACID ANHYDRIDE ENDGROUPS BASF SE (DE) 2018-08-09 WO disclosed
US-6706855-B1 CATIONIC POLY(HEXAMETHYLENEBIGUANIDE) BOUND TO CHROMOPHORIC LABEL AVECIA LIMITED (GB) 2004-03-16 US disclosed
EP-1213967-B1 ANTIMICROBIAL POLYMER AVECIA LTD (GB) 2004-02-04 EP disclosed
EP-1213967-A1 ANTIMICROBIAL POLYMER Avecia Limited (GB) 2002-06-19 EP disclosed
WO-2001017356-A1 ANTIMICROBIAL POLYMER AVECIA LIMITED (GB) 2001-03-15 WO disclosed
US-4782064-A THROMBOXANE SYNTHETASE INHIBITORS AMERICAN CYANAMID CO. (US) 1988-11-01 US disclosed