Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6548881 | 1.00 | APP (0.41) | APPNFE2L2IDO1HSD11B1KDM4A | |
| SCHEMBL3677215 | 0.91 | NFE2L2 (0.43) | APPNFE2L2IDO1HSD11B1KDM4A | |
| SCHEMBL3677218 | 0.91 | NFE2L2 (0.43) | APPNFE2L2IDO1HSD11B1KDM4A | |
| SCHEMBL3803627 | 0.83 | NFE2L2 (0.58) | NFE2L2PTGS1MEN1KMT2A | |
| SCHEMBL3671229 | 0.83 | MGAM (0.42) | NFE2L2IDO1MEN1KMT2A | |
| SCHEMBL3677329 | 0.83 | MAPT (0.42) | NFE2L2IDO1MEN1KMT2A | |
| SCHEMBL3675632 | 0.83 | MAPT (0.42) | NFE2L2IDO1MEN1KMT2A | |
| SCHEMBL3803630 | 0.83 | NFE2L2 (0.58) | NFE2L2PTGS1MEN1KMT2A | |
| SCHEMBL826614 | 0.83 | MAPT (0.42) | NFE2L2IDO1MEN1KMT2A | |
| SCHEMBL3675629 | 0.83 | MAPT (0.42) | NFE2L2IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180024-B1 | Z-STYRYL SULFONE ANTICANCER AGENTS | UNIV TEMPLE (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6576675-B1 | Such as 4-fluorostyryl-4-iodobenzylsulfone; targeting receptor tyrosine kinases | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-06-10 | — | — | US | disclosed |
| EP-1180024-A4 | Z-STYRYL SULFONE ANTICANCER AGENTS | UNIV TEMPLE (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-1180024-A1 | Z-STYRYL SULFONE ANTICANCER AGENTS | Temple University of the Commonwealth System of Higher Education (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000057872-A1 | Z-STYRYL SULFONE ANTICANCER AGENTS | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-10-05 | — | — | WO | disclosed |