Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Demeclocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.71 |
| ▸ | USP2 | O75604 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CASP7 | P55210 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demeclocycline SCHEMBL41286 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL28251348 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL29487284 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL41287 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL23247280 | 0.99 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL29355123 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL20716691 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL20952687 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL3252 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT | |
| Demeclocycline SCHEMBL5503953 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1384479-A1 | Preventing or reducing photosensitivity and/or phototoxicity reactions to antiinfective medications | G.D. SEARLE & CO. (US) | 2004-01-28 | — | — | EP | claimed |
| EP-0741570-B1 | PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO ANTIINFECTIVE MEDICATIONS | SEARLE & CO (US) | 2003-05-07 | — | — | EP | claimed |
| US-6172069-B1 | CONTROLLING TIME OF ADMINISTERING | G. D. SEARLE & COMPANY | 2001-01-09 | — | — | US | claimed |
| EP-0741570-B1 | PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO ANTIINFECTIVE MEDICATIONS | SEARLE & CO (US) | 2003-05-07 | — | — | EP | disclosed |