Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Demeclocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | USP2 | O75604 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CASP7 | P55210 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demeclocycline SCHEMBL20716691 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL13085469 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL3252 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL3253 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL5503953 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL2636809 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL29355123 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL29487284 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL6549174 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 | |
| Demeclocycline SCHEMBL41287 | 0.99 | MEN1 (0.71) | MEN1KMT2ATDP1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11213533-B2 | Combinations comprising dibromopropamidine or diminazene and a tetracycline anti-bacterial agent | UNION therapeutics A/S (DK) | 2022-01-04 | — | — | US | disclosed |
| US-20190201422-A1 | COMBINATIONS COMPRISING DIBROMOPROPAMIDINE OR DIMINAZENE AND A TETRACYCLINE ANTI-BACTERIAL AGENT | UNION therapeutics A/S (DK) | 2019-07-04 | — | — | US | disclosed |
| US-10273468-B2 | Inhibition and diagnostics of emerging tetracycline resistance enzymes | WASHINGTON UNIVERSITY (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190201422-A1 | COMBINATIONS COMPRISING DIBROMOPROPAMIDINE OR DIMINAZENE AND A TETRACYCLINE ANTI-BACTERIAL AGENT | TREH, DDT, DPEP1 | MEN1 700/4885KMT2A 2350/4885TDP1 1255/4885 |
| US-11213533-B2 | Combinations comprising dibromopropamidine or diminazene and a tetracycline anti-bacterial agent | TREH, DDT, DPEP1 | MEN1 700/4885KMT2A 2350/4885TDP1 1255/4885 |
| US-10273468-B2 | Inhibition and diagnostics of emerging tetracycline resistance enzymes | BLVRB, FLAD1, DHFR | MEN1 4691/4885KMT2A 1622/4885TDP1 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.