SCHEMBL6549252

SCHEMBL6549252

C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O[C@H](c1ccnc2ccc(OC)cc12)[C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)c1ccnc2ccc(OC)cc12

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.82
CYP2D6 P10635 6/20 0.82
ALDH1A1 P00352 5/20 0.82
ABCB1 P08183 4/20 0.82
SLC22A1 O15245 3/20 0.82
ABCB11 O95342 3/20 0.82
ADRA2A P08913 3/20 0.82
SLC6A4 P31645 3/20 0.82
OPRM1 P35372 3/20 0.82
SCN1A P35498 3/20 0.82
KCNH2 Q12809 3/20 0.82
SCN2A Q99250 3/20 0.82
SCN3A Q9NY46 3/20 0.82
CYP3A4 P08684 3/20 0.82
HSD17B10 Q99714 3/20 0.82
SLC22A2 O15244 2/20 0.82
MEN1 O00255 2/20 0.82
KMT2A Q03164 2/20 0.82
THRB P10828 1/20 0.82
ABCC4 O15439 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10100394 0.96 KDM4E (0.78) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL10100396 0.96 KDM4E (0.78) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL10102106 0.94 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL3673224 0.94 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL25588913 0.94 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL3680691 0.94 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL10102474 0.94 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL3272863 0.93 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL5866995 0.93 KDM4E (0.79) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1
SCHEMBL5307109 0.93 KDM4E (0.82) KDM4ECYP2D6ALDH1A1ABCB1SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0608307-B1 NEW LIGANDS FOR ASYMMETRIC DIHYDROXYLATION: MULTIPLE CINCHONA ALKALOID UNITS ATTACHED TO A CENTRAL HETEROCYCLIC CORE MASSACHUSETTS INST TECHNOLOGY (US) 2004-02-04 EP disclosed
US-5516929-A USING ALKALOID AROMATIC ETHER DERIVATIVES OF DIHYDROQUININE AND DIHYDROQUINIDINE ALONG WITH OSMIUM COMPOUND, BASE, AND POTASSIUM FERRICYANIDE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1996-05-14 US disclosed
EP-0608307-A1 NEW LIGANDS FOR ASYMMETRIC DIHYDROXYLATION: MULTIPLE CINCHONA ALKALOID UNITS ATTACHED TO A CENTRAL HETEROCYCLIC CORE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1994-08-03 EP disclosed
US-5260461-A Asymmetric dihydroxylation of olefins, osmium tetraoxide stereoselective catalyst, enantiomers, ferricyanide salt MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1993-11-09 US disclosed
US-5227543-A Assymetric dihydroxylation of olefins MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1993-07-13 US disclosed
EP-0543969-A1 HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1993-06-02 EP disclosed
WO-1993007142-A1 NEW LIGANDS FOR ASYMMETRIC DIHYDROXYLATION: MULTIPLE CINCHONA ALKALOID UNITS ATTACHED TO A CENTRAL HETEROCYCLIC CORE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1993-04-15 WO disclosed
EP-0526582-A1 HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1993-02-10 EP disclosed
WO-1992020677-A1 HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1992-11-26 WO disclosed
WO-1991016322-A2 HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1991-10-31 WO disclosed