Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.82 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.82 |
| ▸ | SCN1A | P35498 | 3/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.82 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.82 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.82 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | THRB | P10828 | 1/20 | 0.82 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673224 | 1.00 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL25588913 | 1.00 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL10102106 | 1.00 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL3680691 | 1.00 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL6549252 | 0.94 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL3272863 | 0.93 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL10936769 | 0.93 | KDM4E (0.79) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL5866995 | 0.93 | KDM4E (0.79) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL5307109 | 0.93 | KDM4E (0.82) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 | |
| SCHEMBL3675730 | 0.92 | CYP3A4 (0.78) | KDM4ECYP2D6ALDH1A1ABCB1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006441-B2 | Conjugate addition reactions using bifunctional cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2015-04-14 | — | — | US | disclosed |
| US-20140249313-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | BRANDEIS UNIVERSITY (US) | 2014-09-04 | — | — | US | disclosed |
| US-8765955-B2 | Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2014-07-01 | — | — | US | disclosed |
| US-8722891-B2 | Conjugate addition reactions using bifunctional Cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2014-05-13 | — | — | US | disclosed |
| US-8097750-B2 | Highly enantioselective, converting aromatic and aliphatic aldehydes into optically active aryl and alkyl beta -amino acids | BRANDEIS UNIVERSITY (US) | 2012-01-17 | — | — | US | disclosed |
| US-20110295011-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | BRANDEIS UNIVERSITY (US) | 2011-12-01 | — | — | US | disclosed |
| US-7582764-B2 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids | BRANDEIS UNIVERSITY (US) | 2009-09-01 | — | — | US | disclosed |
| US-7531662-B2 | Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them | BRANDEIS UNIVERSITY (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531662-B2 | Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them | BRANDEIS UNIVERSITY (US) | 2009-05-12 | — | — | US | disclosed |
| US-20080228000-A1 | Cinchona Alkaloid-Catalyzed Asymmetric Mannich Reactions | BRANDEIS UNIVERSITY (US) | 2008-09-18 | — | — | US | disclosed |
| US-7312335-B2 | Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2007-12-25 | — | — | US | disclosed |
| US-20070112199-A1 | Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts | BRANDEIS UNIVERSITY (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070083049-A1 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids | BRANDEIS UNIVERSITY (US) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070083049-A1 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids | ATIC, CBR3, IDH1 | KDM4E 3008/4885CYP2D6 229/4885ALDH1A1 56/4885 |
| US-20070112199-A1 | Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts | AKR1C2, AKR1A1, AKR1B1 | KDM4E 3289/4885CYP2D6 574/4885ALDH1A1 45/4885 |
| US-20080228000-A1 | Cinchona Alkaloid-Catalyzed Asymmetric Mannich Reactions | MANBA, MAN2A1, ASNS | KDM4E 3443/4885CYP2D6 2321/4885ALDH1A1 600/4885 |
| US-20110295011-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | CPNE4, CPN1, NQO1 | KDM4E 4253/4885CYP2D6 333/4885ALDH1A1 88/4885 |
| US-20140249313-A1 | Conjugate Addition Reactions Using Bifunctional Cinchona-Alkaloid-Based Catalysts | CPNE4, CPN1, NQO1 | KDM4E 4253/4885CYP2D6 333/4885ALDH1A1 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.