SCHEMBL6551213

SCHEMBL6551213

CN(C)C1CC(c2ccccc2)CCC1=O

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 1/20 0.46
AKR1C3 P42330 1/20 0.42
AKR1C1 Q04828 1/20 0.42
MAP1LC3B Q9GZQ8 1/20 0.41
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
SLC18A3 Q16572 1/20 0.39
LMNA P02545 1/20 0.38
BRD4 O60885 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18585014 0.79 SRD5A1 (0.49) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL13039616 0.78 SRD5A1 (0.47) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL8920951 0.77 SRD5A1 (0.46) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL3929711 0.76 DDB1 (0.41) MAPT
SCHEMBL3460426 0.75 SRD5A1 (0.45) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL22321333 0.75 SRD5A1 (0.45) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL22048164 0.75 SRD5A1 (0.45) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL28243214 0.75 SRD5A1 (0.45) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL8864229 0.75 SRD5A1 (0.45) SRD5A1AKR1C3AKR1C1GAAMAPT
SCHEMBL3536568 0.75 SRD5A1 (0.45) SRD5A1AKR1C3AKR1C1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1385493-A1 SUBSTITUTED CYCLOHEXAN-1,4-DIAMINE DERIVATIVES WITH CONSTIPATING AND PERIPHERAL ANALGESIC PROPERTIES Grünenthal GmbH (DE) 2004-02-04 EP disclosed
WO-2002089783-A1 SUBSTITUTED CYCLOHEXAN-1,4-DIAMINE DERIVATIVES WITH CONSTIPATING AND PERIPHERAL ANALGESIC PROPERTIES Grünenthal GmbH (DE) 2002-11-14 WO disclosed