Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28136022 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL29031284 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL28669182 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL29263622 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL29145044 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL9670413 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| Bromide SCHEMBL10378020 | 0.98 | HRH1 (0.61) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL28347622 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL7007425 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA | |
| SCHEMBL27915750 | 0.98 | HRH1 (0.67) | HRH1CYP1A2SMN1; SMN2CYP2C19NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576510-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011153509-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-08 | — | — | WO | disclosed |
| EP-1044991-B1 | Process of preparing curable compositions and compositions therefrom | ROHM & HAAS (US) | 2004-02-11 | — | — | EP | disclosed |
| US-6645562-B2 | Drying a coating of a liquid addition oligomer having pendant functional groups; modifying by curing and crosslinking with an unsaturated compound having a reactive group using a free radical catalyst; films, adhesives, coatings, paints and inks | GREENBLATT GARY DAVID (US) | 2003-11-11 | — | — | US | disclosed |
| US-20030069363-A1 | Method of preparing a curable coating and curing thereof | GREENBLATT GARY DAVID (US) | 2003-04-10 | — | — | US | disclosed |
| US-20020137857-A1 | Forming an oligomer containing reactive functional groups,and reacting a modifier that also contains reactive function groups with the oligomer | ROHM AND HAAS COMPANY | 2002-09-26 | — | — | US | disclosed |
| US-6433098-B1 | CROSSLINKING; PHOTOPOLYMERIZATION | ROHM AND HAAS COMPANY | 2002-08-13 | — | — | US | disclosed |
| EP-1044991-A1 | Process of preparing curable compositions and compositions therefrom | ROHM AND HAAS COMPANY (US) | 2000-10-18 | — | — | EP | disclosed |
| CN-1270186-A | Method for preparing curable composition and composition therefrom | ROHM & HAAS (US) | 2000-10-18 | — | — | CN | disclosed |
| CN-1214701-A | Ion Exchange Polymers for Anion Separation | UNIV CALIFORNIA (US) | 1999-04-21 | — | — | CN | disclosed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |