Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | POLM | Q9NP87 | 1/20 | 0.43 |
| ▸ | POLK | Q9UBT6 | 1/20 | 0.43 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.43 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20520147 | 0.81 | PTPN11 (0.42) | KDM4EPOLBPTPN11PPARGPPARA | |
| SCHEMBL20520074 | 0.81 | PTPN11 (0.42) | KDM4EPOLBPTPN11PPARGPPARA | |
| SCHEMBL20520069 | 0.81 | PTPN11 (0.42) | KDM4EPOLBPTPN11PPARGPPARA | |
| SCHEMBL27988636 | 0.81 | ALOX15 (0.55) | KDM4EMEN1RECQLKMT2AALOX15 | |
| SCHEMBL20520016 | 0.81 | PTPN11 (0.41) | KDM4EPOLBPTPN11PPARGPPARA | |
| SCHEMBL30262708 | 0.81 | KDM4E (0.59) | KDM4EMEN1RECQLKMT2AALOX15 | |
| SCHEMBL27834615 | 0.81 | KDM4E (0.59) | KDM4EMEN1RECQLKMT2AALOX15 | |
| SCHEMBL1469997 | 0.80 | ALOX15 (0.53) | KDM4EMEN1RECQLKMT2AALOX15 | |
| SCHEMBL1470610 | 0.80 | ALOX15 (0.53) | KDM4EMEN1RECQLKMT2AALOX15 | |
| SCHEMBL28543511 | 0.80 | ALOX15 (0.53) | KDM4EMEN1RECQLKMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165491-B1 | LTA4 HYDROLASE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2004-02-11 | — | — | EP | claimed |