Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CD69 | Q07108 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57604 | 1.00 | MAPK1 (1.00) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL20516489 | 1.00 | MAPK1 (1.00) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL14520991 | 1.00 | MAPK1 (1.00) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL13575286 | 1.00 | MAPK1 (1.00) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL15504324 | 1.00 | MAPK1 (1.00) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL57603 | 1.00 | MAPK1 (1.00) | MAPK1NOD2ALDH1A1THRBESR1 | |
| N-Acetylglucosamine SCHEMBL28342076 | 0.97 | MAPK1 (0.95) | MAPK1NOD2ALDH1A1THRBESR1 | |
| Sulfuric Acid SCHEMBL3262877 | 0.95 | MAPK1 (0.91) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL31124790 | 0.89 | MAPK1 (0.80) | MAPK1NOD2ALDH1A1THRBESR1 | |
| SCHEMBL23247948 | 0.89 | MAPK1 (0.80) | MAPK1NOD2ALDH1A1THRBESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230380-B1 | ENZYME SUBSTRATES AND ASSAY INVOLVING INTRAMOLECULAR FRET | ICONIX PHARM INC (US) | 2004-02-11 | — | — | EP | disclosed |
| US-6455268-B1 | INCLUDES FLUORESCENT DONOR MOIETY, LINKING GROUP AND ACCEPTOR MOIETY; FOR FLUORESCENT RESONANCE ENERGY TRANSFER (FRET) | ICONIX PHARMACEUTICALS INC. | 2002-09-24 | — | — | US | disclosed |
| EP-1230380-A2 | HYDROLYTIC ENZYME SUBSTRATES AND ASSAY METHOD | Iconix Pharmaceuticals, Inc. (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001036662-A2 | HYDROLYTIC ENZYME SUBSTRATES AND ASSAY METHOD | ICONIX PHARMACEUTICALS, INC. (US) | 2001-05-25 | — | — | WO | disclosed |