SCHEMBL6553046

SCHEMBL6553046

COc1cc(C(=O)OC(=N)CCC(=O)OC(=O)c2ccc(O)c(OC)c2)ccc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B2 P37059 1/20 0.56
KDM4E B2RXH2 1/20 0.53
POLB P06746 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
KMT2A Q03164 4/20 0.53
MEN1 O00255 3/20 0.53
SLC22A6 Q4U2R8 1/20 0.53
SLC22A8 Q8TCC7 1/20 0.53
RAB9A P51151 1/20 0.53
HTT P42858 1/20 0.51
CYP1A2 P05177 1/20 0.48
HSP90AA1 P07900 1/20 0.48
HSP90AB1 P08238 1/20 0.48
BLM P54132 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.46
GAA P10253 1/20 0.46
CYP2D6 P10635 1/20 0.43
ALOX5 P09917 2/20 0.42
OR51E2 Q9H255 1/20 0.42
PTPN7 P35236 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6887250 0.81 ESR1 (0.48) HSD17B2KDM4EPOLBHDAC6KMT2A
SCHEMBL109695 0.80 KDM4E (0.59) HSD17B2KDM4EPOLBHDAC6CYP1A2
SCHEMBL9553296 0.76 KMT2A (0.66) HSD17B2KDM4EPOLBHDAC6KMT2A
SCHEMBL6307975 0.75 MAPT (0.40) POLBKMT2ARAB9ASMN1; SMN2GAA
Methyl Vanillate SCHEMBL25417789 0.74 KMT2A (0.72) HSD17B2KDM4EPOLBHDAC6KMT2A
Methyl Vanillate SCHEMBL275939 0.74 KMT2A (0.72) HSD17B2KDM4EPOLBHDAC6KMT2A
Methyl Vanillate SCHEMBL31157843 0.74 KMT2A (0.72) HSD17B2KDM4EPOLBHDAC6KMT2A
SCHEMBL26908643 0.74 KMT2A (0.72) HSD17B2KDM4EPOLBHDAC6KMT2A
Methyl Vanillate SCHEMBL29640509 0.74 KMT2A (0.72) HSD17B2KDM4EPOLBHDAC6KMT2A
SCHEMBL12137171 0.73 HSD17B2 (0.79) HSD17B2KDM4EPOLBHDAC6KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904396-B1 PRODUCTION OF VANILLIN PLANT BIOSCIENCE LTD (GB) 2004-02-18 EP disclosed
EP-0904396-A2 PRODUCTION OF VANILLIN INSTITUTE OF FOOD RESEARCH (GB) 1999-03-31 EP disclosed
WO-1997035999-A2 PRODUCTION OF VANILLIN INSTITUTE OF FOOD RESEARCH (GB) 1997-10-02 WO disclosed