Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 6/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PAM | P19021 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6553397 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2KMT2APAMHTR2A | |
| SCHEMBL7003638 | 0.84 | GRIK1 (0.49) | GRIK1GRIK2KMT2APAMHTR2A | |
| SCHEMBL16147768 | 0.84 | GRIK1 (0.49) | GRIK1GRIK2KMT2APAMHTR2A | |
| SCHEMBL16147766 | 0.84 | GRIK1 (0.49) | GRIK1GRIK2KMT2APAMHTR2A | |
| SCHEMBL21987027 | 0.83 | GRIK1 (0.65) | GRIK1GRIK2PAMHTR2A | |
| SCHEMBL21987028 | 0.83 | GRIK1 (0.65) | GRIK1GRIK2PAMHTR2A | |
| SCHEMBL1859895 | 0.82 | ALDH1A1 (0.50) | GRIK1GRIK2KMT2AHTR2ANOS2 | |
| SCHEMBL12123422 | 0.81 | HTR2A (0.50) | GRIK1GRIK2KMT2APAMHTR2A | |
| SCHEMBL5835825 | 0.80 | GRIK1 (0.50) | GRIK1GRIK2KMT2APAMHTR2A | |
| SCHEMBL27947171 | 0.80 | HTR2A (0.53) | GRIK1GRIK2KMT2APAMHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070043-B1 | ASYMMETRIC HYDROGENATION | CHIROTECH TECHNOLOGY LTD (GB) | 2004-02-18 | — | — | EP | disclosed |
| EP-1042270-B1 | ASYMMETRIC HYDROGENATION | CHIROTECH TECHNOLOGY LTD (GB) | 2003-04-09 | — | — | EP | disclosed |
| US-6414187-B1 | PREPARING ENANTIOMERICALLY ENRICHED CARBOXYLIC ACID DERIVATIVE BY FORMING SALT OF DEHYDRO PRECURSOR ACID WITH STOICHIOMETRIC AMOUNT OF BASE AND ASYMMETRICALLY HYDROGENATING IN PRESENCE OF COMPLEX COMPRISING RHODIUM AND CHIRAL PHOSPHINE LIGAND | CHIROTECH TECHNOLOGY, LTD. (GB) | 2002-07-02 | — | — | US | disclosed |
| US-6207853-B1 | SUCCINIC ACID DERIVATIVE | CHIROTECH TECHNOLOGY, INC. (GB) | 2001-03-27 | — | — | US | disclosed |
| EP-1070043-A1 | ASYMMETRIC HYDROGENATION | Chirotech Technology Limited (GB) | 2001-01-24 | — | — | EP | disclosed |
| EP-1042270-A1 | ASYMMETRIC HYDROGENATION | Chirotech Technology Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999052852-A1 | ASYMMETRIC HYDROGENATION | CHIROTECH TECHNOLOGY LIMITED (GB) | 1999-10-21 | — | — | WO | disclosed |
| WO-1999031041-A1 | ASYMMETRIC HYDROGENATION | CHIROTECH TECHNOLOGY LIMITED (GB) | 1999-06-24 | — | — | WO | disclosed |