Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175787 | 0.98 | SNCA (0.59) | SNCACYP3A4CSNK2A2CSNK2A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9285006 | 0.96 | SNCA (0.58) | SNCACYP3A4CSNK2A2CSNK2A1ALDH1A1 | |
| SCHEMBL9717267 | 0.93 | SNCA (0.55) | SNCACYP3A4CSNK2A2CSNK2A1ALDH1A1 | |
| SCHEMBL8664863 | 0.93 | SNCA (0.55) | SNCACYP3A4CSNK2A2CSNK2A1ALDH1A1 | |
| Paraben SCHEMBL1146606 | 0.91 | SNCA (0.54) | SNCACYP3A4CSNK2A2CSNK2A1ALDH1A1 | |
| Benzoic Acid SCHEMBL3805160 | 0.91 | CYP3A4 (0.62) | SNCACYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL175786 | 0.90 | SNCA (0.67) | SNCACYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL27564589 | 0.90 | SNCA (0.52) | SNCACYP3A4CSNK2A2CSNK2A1ALDH1A1 | |
| SCHEMBL11873571 | 0.87 | ALDH1A1 (0.63) | SNCACYP3A4ALDH1A1TSHRHSD17B10 | |
| Isophthalic Acid SCHEMBL28712224 | 0.86 | CYP3A4 (0.53) | SNCACYP3A4ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933395-B1 | Polyester molding composition | GEN ELECTRIC (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-0933395-A2 | Polyester molding composition | GENERAL ELECTRIC COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |