Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.61 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6405484 | 0.99 | PARP1 (0.60) | PARP1PARP2KCNH2DRD4TNK2 | |
| SCHEMBL6409266 | 0.87 | PARP1 (0.59) | PARP1PARP2KCNH2DRD4TNK2 | |
| Hydrochloric Acid SCHEMBL6408219 | 0.86 | PARP1 (0.56) | PARP1PARP2KCNH2DRD4TNK2 | |
| Hydrochloric Acid SCHEMBL6408278 | 0.83 | PARP1 (0.66) | PARP1PARP2KCNH2DRD4DRD2 | |
| SCHEMBL6555953 | 0.80 | PARP1 (0.62) | PARP1PARP2KCNH2DRD4TNK2 | |
| Hydrochloric Acid SCHEMBL6407175 | 0.79 | PARP1 (0.61) | PARP1PARP2KCNH2DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL6408406 | 0.79 | PARP1 (0.61) | PARP1PARP2KCNH2DRD4TNK2 | |
| SCHEMBL6554484 | 0.78 | PARP1 (0.66) | PARP1PARP2KCNH2 | |
| SCHEMBL6406734 | 0.78 | PARP1 (0.77) | PARP1PARP2KCNH2 | |
| Hydrochloric Acid SCHEMBL6404360 | 0.78 | PARP1 (0.65) | PARP1PARP2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |