Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.62 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6408406 | 0.99 | PARP1 (0.61) | PARP1PARP2KCNH2TNK2TNK1 | |
| Hydrochloric Acid SCHEMBL6408278 | 0.90 | PARP1 (0.66) | PARP1PARP2KCNH2DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6407175 | 0.88 | PARP1 (0.61) | PARP1PARP2KCNH2DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6409122 | 0.86 | PARP1 (0.58) | PARP1PARP2KCNH2TNK1DRD2 | |
| SCHEMBL6554258 | 0.84 | PARP1 (0.56) | PARP1PARP2KCNH2TNK2TNK1 | |
| Hydrochloric Acid SCHEMBL6405042 | 0.83 | PARP1 (0.55) | PARP1PARP2KCNH2TNK2TNK1 | |
| SCHEMBL6404621 | 0.83 | PARP1 (0.68) | PARP1PARP2KCNH2TNK2TNK1 | |
| Hydrochloric Acid SCHEMBL6554788 | 0.82 | PARP1 (0.67) | PARP1PARP2KCNH2TNK2TNK1 | |
| SCHEMBL6554240 | 0.80 | PARP1 (0.61) | PARP1PARP2KCNH2TNK2TNK1 | |
| Hydrochloric Acid SCHEMBL6405484 | 0.79 | PARP1 (0.60) | PARP1PARP2KCNH2TNK2TNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |