SCHEMBL6554649

SCHEMBL6554649

CC(C)(C)OC(=O)NCCc1cccnc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 1/20 0.56
KDM4E B2RXH2 3/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
IDO1 P14902 4/20 0.46
MEN1 O00255 1/20 0.45
LMNA P02545 1/20 0.45
TSHR P16473 1/20 0.45
KMT2A Q03164 1/20 0.45
CYP3A4 P08684 1/20 0.44
AKT1 P31749 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
HTT P42858 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
POLB P06746 2/20 0.42
BCHE P06276 1/20 0.42
ALDH1A1 P00352 1/20 0.41
GFER P55789 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6991507 0.92 KDM4E (0.48) NQO2KDM4EL3MBTL1MEN1LMNA
SCHEMBL15804093 0.86 NAMPT (0.46) NQO2KDM4EL3MBTL1LMNACYP3A4
SCHEMBL31569162 0.84 NQO2 (0.51) NQO2KDM4EL3MBTL1IDO1MEN1
SCHEMBL30926090 0.83 NQO2 (0.50) NQO2KDM4EL3MBTL1IDO1MEN1
SCHEMBL29844938 0.83 NQO2 (0.59) NQO2KDM4EL3MBTL1IDO1MEN1
SCHEMBL7427034 0.82 NQO2 (0.49) NQO2KDM4EL3MBTL1IDO1MEN1
SCHEMBL5592422 0.81 NQO2 (0.47) NQO2KDM4EL3MBTL1IDO1CYP3A4
SCHEMBL4381773 0.80 NQO2 (0.61) NQO2IDO1MEN1LMNATSHR
SCHEMBL3886074 0.79 MTNR1A (0.70) NQO2IDO1MEN1LMNATSHR
SCHEMBL25056476 0.78 KDM4E (0.45) NQO2KDM4EL3MBTL1IDO1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389185-A2 AMINOALCOHOL DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-02-18 EP disclosed
WO-2002094770-A2 AMINOALCOHOL DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-28 WO disclosed