Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 18/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555021 | 1.00 | ADORA2B (0.73) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9155692 | 0.94 | ADORA2B (0.64) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9155681 | 0.94 | ADORA2B (0.64) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9152046 | 0.93 | ADORA2B (0.68) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9152034 | 0.93 | ADORA2B (0.68) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9159465 | 0.93 | ADORA2B (0.66) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9159455 | 0.93 | ADORA2B (0.66) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9157110 | 0.92 | ADORA2B (0.65) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9157123 | 0.92 | ADORA2B (0.65) | ADORA2BADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL9155023 | 0.92 | ADORA2B (0.65) | ADORA2BADORA2AADORA3ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004523559-A | — | — | 2004-08-05 | — | — | JP | claimed |
| EP-1372661-A2 | METHODS OF TREATING IRRITABLE BOWEL SYNDROME AND FUNCTIONAL DYSPEPSIA | SmithKline Beecham Corporation (US) | 2004-01-02 | — | — | EP | claimed |
| WO-2002067942-A2 | METHODS OF TREATING IRRITABLE BOWEL SYNDROME AND FUNCTIONAL DYSPEPSIA | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-06 | — | — | WO | claimed |
| EP-0639055-A1 | METHODS OF TREATING OBESITY WITH PURINE RELATED COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1995-02-22 | — | — | EP | claimed |
| WO-1993021783-A1 | METHODS OF TREATING OBESITY WITH PURINE RELATED COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1993-11-11 | — | — | WO | claimed |
| EP-0203721-B1 | 8-PHENYL XANTHINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-10 | — | — | EP | claimed |
| US-4980379-A | ENHANCING EFFICIENCY BY REDUCING ADENOSINE LEVELS | THE UNIVERSITY OF VIRGINIA (US) | 1990-12-25 | — | — | US | claimed |
| US-4879296-A | BLOCKING ADERNOSINE CELL SURFACE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1989-11-07 | — | — | US | claimed |
| EP-0203721-A2 | 8-Phenyl xanthines | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-12-03 | — | — | EP | claimed |
| EP-1104422-B1 | PHENYL XANTHINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-02-18 | — | — | EP | disclosed |
| EP-1372661-A2 | METHODS OF TREATING IRRITABLE BOWEL SYNDROME AND FUNCTIONAL DYSPEPSIA | SmithKline Beecham Corporation (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002067942-A2 | METHODS OF TREATING IRRITABLE BOWEL SYNDROME AND FUNCTIONAL DYSPEPSIA | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-06 | — | — | WO | disclosed |
| EP-1104422-A1 | PHENYL XANTHINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-06-06 | — | — | EP | disclosed |
| US-6166032-A | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 2000-12-26 | — | — | US | disclosed |
| US-5017577-A | Using Purine Cinnamic Acids | BURROUGHS WELLCOME CO. (US) | 1991-05-21 | — | — | US | disclosed |
| US-5015647-A | Using Purine Cinnamic Acid Compounds | BURROUGHS WELLCOME CO. (US) | 1991-05-14 | — | — | US | disclosed |
| US-4981857-A | ADENOSINE ANTAGONIST | BURROUGHS WELLCOME CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4980379-A | ENHANCING EFFICIENCY BY REDUCING ADENOSINE LEVELS | THE UNIVERSITY OF VIRGINIA (US) | 1990-12-25 | — | — | US | disclosed |
| US-4879296-A | BLOCKING ADERNOSINE CELL SURFACE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1989-11-07 | — | — | US | disclosed |
| EP-0203721-A2 | 8-Phenyl xanthines | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-12-03 | — | — | EP | disclosed |