Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556831 | 0.84 | MEN1 (0.47) | NTRK1KMT2AMEN1MAP2K7MAP2K4 | |
| SCHEMBL4008915 | 0.81 | NTRK1 (0.52) | NTRK1PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL4013522 | 0.81 | POLB (0.52) | NTRK1KMT2APOLBCSNK2A1 | |
| SCHEMBL4009500 | 0.80 | BRAF (0.45) | KMT2APOLBMEN1CSNK2A1GAA | |
| SCHEMBL4003137 | 0.79 | TSHR (0.52) | NTRK1MAP2K7MAP2K4BRAF | |
| SCHEMBL4009872 | 0.75 | CSNK2A1 (0.55) | KMT2APOLBCSNK2A1DYRK3MAP4K4 | |
| SCHEMBL4010682 | 0.75 | ACLY (0.57) | PIK3CDKMT2AACLYMEN1ROCK2 | |
| SCHEMBL1461004 | 0.74 | NTRK1 (0.56) | NTRK1MAP2K7MAP2K4 | |
| SCHEMBL1460972 | 0.74 | MEN1 (0.55) | NTRK1KMT2AACLYMEN1CSNK2A1 | |
| SCHEMBL4008270 | 0.74 | MAPT (0.60) | KMT2AMEN1MAP2K7MAP2K4CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487803-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078402-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |