SCHEMBL6556284

SCHEMBL6556284

COc1ccc(-c2ncc(NC(=O)OCc3ccccc3)c(=O)n2CC(=O)O)cc1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 19/20 0.71
TACR3 P29371 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6556362 0.91 ELANE (0.63) ELANE
SCHEMBL6085435 0.91 ELANE (0.67) ELANE
SCHEMBL6558418 0.89 ELANE (0.64) ELANETACR3
SCHEMBL6556407 0.88 ELANE (0.69) ELANE
SCHEMBL6557728 0.88 ELANE (0.70) ELANE
SCHEMBL6556218 0.87 ELANE (0.60) ELANE
SCHEMBL6556239 0.86 ELANE (0.64) ELANE
SCHEMBL6557667 0.86 ELANE (0.63) ELANETACR3
SCHEMBL6558186 0.85 ELANE (0.71) ELANE
SCHEMBL6799310 0.84 RAB9A (0.54) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0826671-B1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME MITSUBISHI PHARMA CORP (JP) 2004-12-29 EP disclosed
US-5948785-A USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. THE GREEN CROSS CORPORATION (JP) 1999-09-07 US disclosed
EP-0826671-A1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME THE GREEN CROSS CORPORATION (JP) 1998-03-04 EP disclosed