Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556375 | 1.00 | SIGMAR1 (0.50) | SIGMAR1MCHR1LMNAGAAKDM4E | |
| SCHEMBL6556380 | 1.00 | SIGMAR1 (0.50) | SIGMAR1MCHR1LMNAGAAKDM4E | |
| SCHEMBL6556593 | 1.00 | SIGMAR1 (0.50) | SIGMAR1MCHR1LMNAGAAKDM4E | |
| SCHEMBL6556584 | 0.90 | SIGMAR1 (0.47) | SIGMAR1MCHR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6558569 | 0.90 | SIGMAR1 (0.47) | SIGMAR1MCHR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6558571 | 0.90 | SIGMAR1 (0.47) | SIGMAR1MCHR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6556413 | 0.90 | SIGMAR1 (0.47) | SIGMAR1MCHR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6556471 | 0.88 | GAA (0.45) | SIGMAR1LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL6556481 | 0.88 | GAA (0.45) | SIGMAR1LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL6556478 | 0.88 | GAA (0.45) | SIGMAR1LMNAGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |