Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.66 |
| ▸ | BRD4 | O60885 | 11/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457720 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL31525496 | 0.73 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL6556535 | 0.72 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13677930 | 0.71 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL6755741 | 0.71 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6558457 | 0.71 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL18117748 | 0.71 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL10760806 | 0.70 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL31525503 | 0.69 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL6556640 | 0.69 | CYP3A4 (0.42) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| CN-1113872-C | Tricyclicbenzo [3] isoindole and benzo (h) isoquinoline | HOFFMANN LA ROCHE (CH) | 2003-07-09 | — | — | CN | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |
| CN-1243510-A | Tricyclicbenzo [3] isoindole and benzo (h) isoquinoline | HOFFMANN LA ROCHE (CH) | 2000-02-02 | — | — | CN | disclosed |
| EP-0958285-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030546-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-16 | — | — | WO | disclosed |