Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | VEGFA | P15692 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11709072 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7293719 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5326457 | 0.78 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5350832 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5329316 | 0.76 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL11099921 | 0.75 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3314817 | 0.75 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL11459402 | 0.75 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5324227 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5331581 | 0.74 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| CN-1113872-C | Tricyclicbenzo [3] isoindole and benzo (h) isoquinoline | HOFFMANN LA ROCHE (CH) | 2003-07-09 | — | — | CN | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |
| CN-1243510-A | Tricyclicbenzo [3] isoindole and benzo (h) isoquinoline | HOFFMANN LA ROCHE (CH) | 2000-02-02 | — | — | CN | disclosed |
| EP-0958285-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030546-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-16 | — | — | WO | disclosed |