Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5166546 | 0.99 | CHRNA7 (0.58) | CHRNA7KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL30965967 | 0.86 | CHRNA7 (0.55) | CHRNA7KMT2AMEN1 | |
| SCHEMBL28686105 | 0.86 | CHRNA7 (0.55) | CHRNA7KMT2AMEN1 | |
| SCHEMBL14540064 | 0.85 | SMN1; SMN2 (0.52) | L3MBTL1ALDH1A1HTTGAASMN1; SMN2 | |
| SCHEMBL6554336 | 0.85 | CHRNA7 (0.44) | CHRNA7KMT2ANPC1RAB9A | |
| SCHEMBL1459331 | 0.85 | CHRNA7 (0.44) | CHRNA7KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5168545 | 0.84 | SMN1; SMN2 (0.54) | L3MBTL1ALDH1A1HTTGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5167272 | 0.84 | CHRNA7 (0.43) | CHRNA7KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL1460457 | 0.84 | PTPN1 (0.48) | KDM4EALDH1A1HTTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL5170194 | 0.83 | PTPN1 (0.47) | KMT2AMEN1KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487834-B1 | AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | BAYER HEALTHCARE AG (DE) | 2007-04-25 | — | — | EP | disclosed |
| EP-1487834-A1 | AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | Bayer Aktiengesellschaft (DE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078431-A1 | AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | BAYER HEALTHCARE AG (DE) | 2003-09-25 | — | — | WO | disclosed |