Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591285 | 0.95 | — | — | |
| SCHEMBL72471 | 0.82 | LMNA (0.62) | LMNATSHRMAPTHTTCYP2D6 | |
| SCHEMBL155921 | 0.81 | LMNA (0.63) | LMNATSHRMAPTCYP4F2CYP4A11 | |
| SCHEMBL31402602 | 0.79 | LMNA (0.60) | LMNATSHRMAPTHTTCYP2D6 | |
| Hydrochloric Acid SCHEMBL6385125 | 0.79 | LMNA (0.61) | LMNATSHRMAPTCYP4F2CYP4A11 | |
| Isopropyl Alcohol SCHEMBL811815 | 0.79 | LMNA (0.50) | LMNATSHRMAPTHTTCYP2D6 | |
| SCHEMBL3505201 | 0.79 | LMNA (0.67) | LMNATSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL1278227 | 0.77 | LMNA (0.70) | LMNAMAPTMAPK1ALDH1A1GAA | |
| SCHEMBL3504067 | 0.77 | LMNA (0.70) | LMNAMAPTMAPK1ALDH1A1GAA | |
| SCHEMBL3503956 | 0.77 | LMNA (0.70) | LMNAMAPTMAPK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1197491-B1 | Thioxanthenone antitumor agents | SANOFI AVENTIS (FR) | 2004-12-29 | — | — | EP | disclosed |
| EP-0917458-B1 | LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS | SANOFI SYNTHELABO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0882723-B1 | Thioxanthenone antitumor agents | SANOFI SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| EP-1197491-A1 | Thioxanthenone antitumor agents | SANOFI-SYNTHELABO (FR) | 2002-04-17 | — | — | EP | disclosed |
| EP-0619315-B1 | Thioxanthenone antitumor agents | SANOFI SA (FR) | 1999-06-09 | — | — | EP | disclosed |
| EP-0917458-A1 | LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS | SANOFI (FR) | 1999-05-26 | — | — | EP | disclosed |
| EP-0882723-A1 | Thioxanthenone antitumor agents | SANOFI (FR) | 1998-12-09 | — | — | EP | disclosed |
| US-5665760-A | Lyophilized thioxanthenone antitumor agents | SANOFI WINTHROP, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997010809-A1 | LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS | SANOFI (FR) | 1997-03-27 | — | — | WO | disclosed |
| US-5380749-A | Thioxanthenone antitumor agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0619315-A1 | Thioxanthenone antitumor agents | STERLING WINTHROP INC. (US) | 1994-10-12 | — | — | EP | disclosed |
| US-5346917-A | For mammals | STERLING WINTHROP INC. (US) | 1994-09-13 | — | — | US | disclosed |