Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5929911 | 1.00 | CTSB (0.54) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5929888 | 1.00 | CTSB (0.54) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6443918 | 0.93 | CTSB (0.57) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6443922 | 0.93 | CTSB (0.57) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5930084 | 0.92 | KLK5 (0.47) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8331508 | 0.89 | CTSB (0.54) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5929768 | 0.89 | CTSB (0.56) | CTSBSPPL2ATRPM8 | |
| SCHEMBL5929818 | 0.89 | CTSB (0.56) | CTSBSPPL2ATRPM8 | |
| SCHEMBL8331942 | 0.87 | PSEN1 (0.51) | CTSBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8332535 | 0.87 | PSEN1 (0.53) | CTSBPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392645-A2 | AZA HYDROXYLATED ETHYL AMINE COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002094768-A2 | AZA HYDROXYLATED ETHYL AMINE COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2002-11-28 | — | — | WO | disclosed |