Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 4/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557194 | 1.00 | AXL (0.43) | AXLITKBRD4ATAD2IDH2 | |
| SCHEMBL6559230 | 0.88 | AXL (0.43) | AXLITKBRD4ATAD2IDH2 | |
| SCHEMBL6559451 | 0.87 | KDM1A (0.47) | AXLITKIDH2HRH4PRKCQ | |
| SCHEMBL6559446 | 0.87 | KDM1A (0.47) | AXLITKIDH2HRH4PRKCQ | |
| SCHEMBL14614704 | 0.86 | AXL (0.45) | AXLITKBRD4ATAD2PRKCQ | |
| SCHEMBL21460340 | 0.86 | AXL (0.45) | AXLITKBRD4ATAD2PRKCQ | |
| SCHEMBL21727343 | 0.79 | PTGS1 (0.51) | PTGS1PTGS2RAPGEF4 | |
| SCHEMBL21533591 | 0.79 | BRD4 (0.45) | AXLITKBRD4ATAD2PRKCQ | |
| SCHEMBL5390131 | 0.79 | PRKCQ (0.43) | AXLITKBRD4ATAD2PRKCQ | |
| Hydrochloric Acid SCHEMBL5382559 | 0.78 | PRKCQ (0.42) | AXLITKBRD4ATAD2PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392651-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090326-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |