Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559446 | 1.00 | KDM1A (0.47) | KDM1AMAOBAPPAXLIDH2 | |
| SCHEMBL1704674 | 0.89 | KDM1A (0.53) | KDM1AMAOBAPPNPC1RAB9A | |
| SCHEMBL6557199 | 0.87 | AXL (0.43) | AXLIDH2PRKCQITKHTR6 | |
| SCHEMBL6559230 | 0.87 | AXL (0.43) | KDM1AMAOBAXLIDH2PRKCQ | |
| SCHEMBL6557194 | 0.87 | AXL (0.43) | AXLIDH2PRKCQITKHTR6 | |
| SCHEMBL4634218 | 0.82 | HTR6 (0.46) | AXLIDH2ITKHTR6HRH4 | |
| SCHEMBL18244581 | 0.79 | ALDH1A1 (0.42) | AXL | |
| SCHEMBL18244580 | 0.79 | ALDH1A1 (0.42) | AXL | |
| SCHEMBL245476 | 0.79 | NPC1 (0.49) | KDM1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21460342 | 0.79 | NOS2 (0.42) | KDM1AMAOBAXLIDH2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392651-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090326-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |