Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555409 | 0.89 | DHFR (0.64) | DHFR | |
| SCHEMBL6555538 | 0.85 | DHFR (0.60) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL6555444 | 0.84 | DHFR (0.61) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL6555131 | 0.84 | DHFR (0.63) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL6557326 | 0.83 | DHFR (0.61) | DHFR | |
| SCHEMBL6555242 | 0.83 | DHFR (0.55) | DHFR | |
| SCHEMBL6555413 | 0.83 | DHFR (0.55) | DHFR | |
| SCHEMBL6555401 | 0.83 | DHFR (0.62) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL6557526 | 0.83 | DHFR (0.66) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| SCHEMBL6557512 | 0.82 | DHFR (0.59) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1186328-C | Substd. 5-benzyl-2,4-diaminopyrimidines | BASLIDE PHARMA AG (CH) | 2005-01-26 | — | — | CN | disclosed |
| EP-1230224-B1 | SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2004-12-29 | — | — | EP | disclosed |
| US-6821980-B1 | Substituted 5-benzyl-2,4-diaminopyrimidines | BASILEA PHARMACEUTICA AG (CH) | 2004-11-23 | — | — | US | disclosed |
| EP-1230224-A1 | SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032633-A1 | SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2001-05-10 | — | — | WO | disclosed |