Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422007 | 0.93 | POLB (0.61) | POLBTSHRKMT2AALDH1A1HPGD | |
| SCHEMBL17804391 | 0.81 | TP53 (0.43) | TSHRALDH1A1KDM4EL3MBTL1MAPK1 | |
| SCHEMBL2420937 | 0.77 | POLB (0.39) | POLBTSHRKMT2AALDH1A1HPGD | |
| SCHEMBL2430488 | 0.77 | CA12 (0.67) | POLBTSHRALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1546827 | 0.75 | POLB (0.87) | POLBTSHRKMT2AALDH1A1HPGD | |
| SCHEMBL932571 | 0.74 | CA1 (0.50) | CA1CA2 | |
| SCHEMBL19710564 | 0.74 | PSEN1 (0.42) | KMT2ALMNAMEN1 | |
| SCHEMBL21510037 | 0.74 | PSEN1 (0.42) | KMT2ALMNAMEN1 | |
| SCHEMBL7955480 | 0.73 | POLB (0.56) | POLBTSHRKMT2AALDH1A1HPGD | |
| SCHEMBL5280013 | 0.72 | POLB (0.93) | POLBTSHRKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436255-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003024924-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2003-03-27 | — | — | WO | claimed |