Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556390 | 0.74 | HTR2A (0.37) | MEN1KMT2ANPSR1ALDH1A1MAPT | |
| SCHEMBL6556400 | 0.74 | HTR2A (0.37) | MEN1KMT2ANPSR1ALDH1A1MAPT | |
| SCHEMBL6556396 | 0.74 | HTR2A (0.37) | MEN1KMT2ANPSR1ALDH1A1MAPT | |
| SCHEMBL6556316 | 0.74 | HTR2A (0.37) | MEN1KMT2ANPSR1ALDH1A1MAPT | |
| SCHEMBL6556509 | 0.72 | SIGMAR1 (0.46) | — | |
| Fumaric Acid SCHEMBL6556317 | 0.71 | TSHR (0.35) | MEN1MAPK1KMT2ANPSR1GAA | |
| Fumaric Acid SCHEMBL6556476 | 0.71 | TSHR (0.35) | MEN1MAPK1KMT2ANPSR1GAA | |
| Fumaric Acid SCHEMBL7868759 | 0.71 | TSHR (0.35) | MEN1MAPK1KMT2ANPSR1GAA | |
| SCHEMBL3071759 | 0.66 | MAPK1 (0.40) | MEN1MAPK1KMT2AGAAALOX12 | |
| SCHEMBL3071763 | 0.66 | MAPK1 (0.40) | MEN1MAPK1KMT2AGAAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |