Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 13/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 13/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498477 | 0.79 | SPHK2 (0.44) | SPHK2SPHK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL218318 | 0.78 | NR4A2 (0.36) | RAB9A | |
| SCHEMBL31374411 | 0.73 | HSP90AA1 (0.56) | SPHK2SPHK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL11614665 | 0.73 | SPHK2 (0.51) | SPHK2SPHK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL13093801 | 0.72 | SPHK2 (0.58) | SPHK2SPHK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL6558546 | 0.71 | SPHK2 (0.46) | SPHK2SPHK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL167744 | 0.69 | — | — | |
| SCHEMBL19320611 | 0.69 | TP53 (0.41) | HSP90AA1RAB9A | |
| SCHEMBL5760240 | 0.69 | MEN1 (0.59) | CYP1A2RAB9A | |
| SCHEMBL4539976 | 0.69 | RAB9A (0.49) | CYP1A1CYP1A2CYP1B1HSP90AA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100762-B1 | ERYTHROMYCIN DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZAMBON SPA (IT) | 2004-03-10 | — | — | EP | disclosed |
| US-6468979-B1 | ERYTHROMYCIN DERIVATIVES WITH BIHETEROCYCLIC GROUP AS SUBSTITUENT AT END OF CHAIN HAVE PARTICULARLY BROAD SPECTRUM OF ACTIVITY AND LONG DURATION OF ACTION | ZAMBON GROUP S.P.A. (IT) | 2002-10-22 | — | — | US | disclosed |
| EP-1100762-A2 | ERYTHROMYCIN DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006606-A2 | ERYTHROMYCIN DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2000-02-10 | — | — | WO | disclosed |