SCHEMBL6558252

SCHEMBL6558252

O=C(NCCc1ccc(C(=O)Cl)cc1F)OCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HTT P42858 1/20 0.48
IDO1 P14902 1/20 0.47
KCNA5 P22460 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
MAPT P10636 1/20 0.45
KAT2B Q92831 1/20 0.44
TGM2 P21980 1/20 0.44
TRPM8 Q7Z2W7 1/20 0.43
KEAP1 Q14145 2/20 0.43
NFE2L2 Q16236 2/20 0.43
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
SLC1A3 P43003 1/20 0.41
SLC1A1 P43005 1/20 0.41
ALDH1A1 P00352 1/20 0.41
KMT2A Q03164 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6560301 0.91 LMNA (0.52) LMNASMN1; SMN2HTTIDO1KCNA5
SCHEMBL6557683 0.87 LMNA (0.51) LMNASMN1; SMN2HTTIDO1L3MBTL1
SCHEMBL19210898 0.83 LMNA (0.52) LMNASMN1; SMN2HTTIDO1KCNA5
SCHEMBL28687598 0.83 LMNA (0.52) LMNASMN1; SMN2HTTIDO1KCNA5
SCHEMBL29707309 0.83 LMNA (0.52) LMNASMN1; SMN2HTTIDO1KCNA5
SCHEMBL6557803 0.83 SMN1; SMN2 (0.51) LMNASMN1; SMN2HTTIDO1L3MBTL1
SCHEMBL22957446 0.81 SMN1; SMN2 (0.50) LMNASMN1; SMN2HTTIDO1KCNA5
SCHEMBL19212041 0.81 PTGDR2 (0.51) LMNASMN1; SMN2HTTIDO1KCNA5
SCHEMBL6558232 0.81 SMN1; SMN2 (0.58) LMNASMN1; SMN2HTTIDO1L3MBTL1
SCHEMBL6557916 0.81 POLB (0.55) LMNASMN1; SMN2IDO1KCNA5HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1391454-A1 Substituted benzamide compounds with antihypertensive activity Mitsubishi Pharma Corporation (JP) 2004-02-25 EP disclosed
EP-1195372-A1 N-heterocyclic substituted benzamide derivatives with antihypertensive activity Mitsubishi Pharma Corporation (JP) 2002-04-10 EP disclosed
US-6156766-A Benzamide compounds and pharmaceutical use thereof YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-12-05 US disclosed
US-5958944-A TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-09-28 US disclosed
EP-0757038-A1 BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-02-05 EP disclosed