Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21436568 | 0.97 | SLC2A1 (0.60) | SLC2A1CYP3A4CYP3A5CYP19A1HTR2A | |
| SCHEMBL2131459 | 0.84 | CYP3A4 (0.60) | CYP3A4CYP3A5CYP19A1HTR2AHTR2C | |
| SCHEMBL30114522 | 0.84 | CYP3A4 (0.60) | CYP3A4CYP3A5CYP19A1HTR2AHTR2C | |
| SCHEMBL1450207 | 0.82 | SLC2A1 (0.83) | SLC2A1CYP3A4CYP19A1CRHBPCRHR2 | |
| SCHEMBL14384030 | 0.82 | SLC2A1 (0.83) | SLC2A1CYP3A4CYP19A1CRHBPCRHR2 | |
| SCHEMBL7590526 | 0.82 | SLC2A1 (0.58) | SLC2A1CYP3A4HTR2AHTR2CADRA1A | |
| SCHEMBL14156831 | 0.81 | CYP3A4 (0.55) | CYP3A4CYP3A5CYP19A1HTR2AHTR2C | |
| SCHEMBL675338 | 0.81 | CYP3A4 (0.71) | CYP3A4CYP3A5CYP19A1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL29837416 | 0.81 | SLC2A1 (0.79) | SLC2A1CYP3A4CYP19A1CRHBPCRHR2 | |
| SCHEMBL6369689 | 0.80 | KCNN4 (0.57) | CYP3A4CYP3A5CYP19A1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | claimed |
| JP-2002521430-A | — | — | 2002-07-16 | — | — | JP | claimed |
| EP-1100483-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | Abbott Laboratories (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2000006137-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1100483-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | Abbott Laboratories (US) | 2001-05-23 | — | — | EP | disclosed |
| US-6166013-A | Glucocortiocoid-selective agents | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000006137-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | disclosed |