Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 4/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559337 | 0.88 | KCNE1 (0.47) | KCNE1KCNQ1LMNATRPV1ALDH1A1 | |
| SCHEMBL6559313 | 0.83 | KCNE1 (0.46) | KCNE1KCNQ1LMNANPSR1TSHR | |
| SCHEMBL6559524 | 0.81 | KCNE1 (0.57) | KCNE1KCNQ1LMNATRPV1ALDH1A1 | |
| SCHEMBL6559544 | 0.76 | KCNA5 (0.36) | KCNE1KCNQ1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6601915 | 0.75 | KCNE1 (0.57) | KCNE1KCNQ1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6560836 | 0.73 | KCNA5 (0.34) | KCNE1KCNQ1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6559417 | 0.72 | KCNE1 (0.37) | KCNE1KCNQ1TRPV1KMT2A | |
| SCHEMBL6559266 | 0.72 | KCNE1 (0.52) | KCNE1KCNQ1TRPV1 | |
| SCHEMBL6559403 | 0.72 | KCNA5 (0.37) | LMNANPSR1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL6559500 | 0.72 | NPSR1 (0.38) | KCNE1KCNQ1NPSR1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |